DPP4ResearchGroup @ Flinders University

I hug myself, I regulate my citizen, I govern my state

Who we are

We are a group of researchers studying the molecular bases, evolution and clinical implications of a family of proteases, namely dipeptidyl peptidases-4 (DPP4) family. We are based in Flinders University at Bedford Park, which is located just on the outskirt of the beautiful Adelaide, Australia. Check out this portfolio to see more of Flinders and Adelaide.

What the hack is Dipeptidyl peptidase - 4 (DPP4) family

DPP4 family is a sub-family of serine proteases, three of its members (DPP4, DPP8 and DPP9) possess a rare ability to hydrolysis the peptides after penultimate proline. This hydrolytic potency enables DPP4 family proteases to regulate some important biological molecules including but not limited to metabolic hormones and a broad spectrum of cytokines 1. In addition, DPP4 family proteases also known to function as antigens on various cell surface. Consequently, DPP4 family have profound implications in cellular homeostasis regulations and various cancer development2.

References

  1. GORRELL, Mark D, ‘Dipeptidyl Peptidase IV and Related Enzymes in Cell Biology and Liver Disorders’, Clinical Science, vol. 108, no. 4, 2005, 277-92. ↩

  2. Yazbeck, R, SE Jaenisch, & CA Abbott, ‘Potential Disease Biomarkers: Dipeptidyl Peptidase 4 and Fibroblast Activation Protein’, Protoplasma, 2017. ↩